NTHRYS › Internships › Molecular Microbiology

Microbial Secondary Metabolite Biosynthesis Pathways

Molecular Microbiology

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Microbial Secondary Metabolite Biosynthesis Pathways

Research internship analyzing nonribosomal peptide synthase and polyketide synthase gene clusters using bioinformatics and heterologous expression.

The focused areas below are internship topics in varied working formats. Pick one, then choose your internship type, mode… Read more

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📚 Academic: Thesis & PPT assistance included🧪 Tech: Master the protocols hands-on📝 Research > 3 months: Publication co-authorship in a Scopus-indexed journal

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Showing 1–5 of 5

Polyketide Synthase (PKS) Pathway Engineering

Interns will investigate the modular architecture of polyketide synthases and learn techniques for heterologous expression and pathway reconstruction. They will work on manipulating PKS domains to produce novel bioactive compounds with potential pharmaceutical applications.

Academic (A)Tech (T)Research (R)

14 more durationsView Titles →

Non-Ribosomal Peptide (NRP) Biosynthesis Characterization

This internship focuses on elucidating non-ribosomal peptide synthetase (NRPS) gene clusters using bioinformatic analysis and functional genomics approaches. Interns will identify and validate adenylation domain specificity and predict novel NRP structures from microbial isolates.

Academic (A)Tech (T)Research (R)

14 more durationsView Titles →

Terpene Biosynthesis and Sesquiterpene Production Optimization

Interns will study terpene synthase enzymes and their role in producing antimicrobial and aromatic secondary metabolites. They will optimize fermentation conditions and employ metabolic engineering strategies to enhance sesquiterpene yields in engineered microbial strains.

Academic (A)Tech (T)Research (R)

14 more durationsView Titles →

Bacterial Natural Product Discovery from Environmental Samples

This internship involves isolating actinomycetes and other secondary metabolite-producing microorganisms from soil and marine samples, followed by crude extract screening and bioactive compound purification. Interns will apply liquid chromatography-mass spectrometry (LC-MS) to identify novel natural products.

Academic (A)Tech (T)Research (R)

14 more durationsView Titles →

Regulatory Mechanisms and Global Gene Expression in Secondary Metabolism

Interns will investigate transcriptional regulators such as pathway-specific transcription factors and cross-pathway regulators that control secondary metabolite biosynthesis. They will use RT-qPCR and RNA-seq analysis to understand metabolic switches and nutrient-dependent gene expression patterns in microorganisms.

Academic (A)Tech (T)Research (R)

14 more durationsView Titles →